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That being said, SARMs are much easier to get than steroids, and many SARMs are given out in safe doses." It is estimated that the worldwide market for legal synthetic testosterone is between $1 and $2 billion. What is a SARM? A SARM—short for selective estrogen receptor modulator, or a receptor—is a synthetic variant of a hormone. They typically are prescribed to women as the first-line treatment in their management of male hypogonadism and as a part of a family of drugs—called aromatase inhibitors—they have been used to treat female fertility issues throughout the history of medicine. They are synthetic versions of hormones that in humans are produced by glands in the ovaries that belong to the Testosterone category. They are also called TRT, or Testosterone Replacement Therapy. The term SARMs was created by the National Institute of Drug Abuse in 2006 when it was discovered that a substance called 5-alpha-reductase deficiency caused the symptoms of testosterone deficiency—inability to get and maintain an erection—as well as a loss of secondary sex characteristics such as chest hair, facial hair growth, and hairiness. A search for the cause failed to turn up a definitive and accepted explanation for the male hormone deficiency. Scientists, doctors and others have tried various methods, both clinical and basic, with varying success, but they all lead to a similar conclusion: the development of symptoms in males that are consistent with low testosterone. The first SARMs were developed in the 1970s, but in 1994 one of the first clinical studies to evaluate them came out—a study led by an NIH postdoctoral fellow called Robert Fisman (now a professor at the University of Chicago School of Medicine). To start this initial study, Fisman and his colleagues recruited 15 male hypogonadal men in San Diego. One-sixth of that group was randomly assigned to receive two months of injections of either testosterone cypionate, or a placebo. The placebo group would receive a placebo; the other 10 would receive injections of either testosterone cypionate or a placebo. The men who received the injections of the testosterone cypionate (an enzyme cypionate, a synthetic version of testosterone that does not have a similar side effect of low testosterone effects) experienced a marked improvement in the secondary sexual characteristics that have previously been linked to low testosterone levels. After two months, two out of 13 women who received the injections were more likely to report positive symptoms (sexually transmitted infections, sexual desire and arousal, fatigue) than women in the placebo group. Related Article: